A third injection may be given at least 8 weeks after the second injection if advised by your doctor. xref 0000013285 00000 n To get around the problem, scientists used virus from a chimpanzee to ensure people would not have any natural immunity to it. 0000015344 00000 n A new investigational treatment for COVID-19: Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. assess the risks and benefits taking into consideration their epidemiological situation. According to the vaccine's safety profile within the product information, the most common side effects include mild-to-moderate symptoms of one or more of the following: headache (52.6%) fatigue . How to store COVID-19 Vaccine AstraZeneca 6. /Root 55 0 R With Australia's COVID vaccine rollout slowly getting underway, what's inside the Pfizer and Astrazeneca jabs is the question now front and centre for a growing number of people hesitant about getting the vaccination.. Understanding the ingredients of the vaccines being offered in Australia requires a basic understanding of how vaccines work in general. No data are currently available in individuals with a weakened immune system or who are taking chronic treatment that suppresses or prevents immune responses. 0000007190 00000 n endobj 0000005016 00000 n 57 40 RZ%L ?Gss0~ls"+?H~9~ ~~g5-?K~=2_H 0000054470 00000 n Vaccine AstraZeneca and those who received control. 0000009283 00000 n Contents of the pack and other information 1. This Oxford-AstraZeneca vaccine uses the ChAdOx1 technology, which has been developed and optimised by the Jenner Institute over the last 10 years. Other reactions reported in this group include muscle aches (60%), malaise (61%), chills (56%), and feeling feverish (51%). 581 0 obj <>stream Generic name: SARS-CoV-2 vaccine Once this enters the body, it tells your cells to make copies of the spike protein. 56 0 obj Electronic address . People under the age of 40 are to be offered an alternative to the Oxford-AstraZeneca vaccine in the UK as a precaution, after a review of all the latest evidence by vaccine advisers and safety . The vaccine is safe and effective for all individuals aged 18 and above. If you are allergic to any of the active substances or any of the other ingredients listed in section 6. Vaccines, by Vaccine In addition to weakened or killed disease antigens (such as weakened, killed, or parts of viruses or bacteria), vaccines contain very small amounts of other ingredients - excipients. Excipients are the non-active ingredients that are added to the vaccine for a variety of reasons. During use it can be stored from 2C to 25C. If you get any side effects, talk to your doctor, pharmacist or nurse. %PDF-1.7 % As new data become available, WHO will update recommendations accordingly. An email has been sent to you to confirm your subscription. 5. There are limited data on the use of COVID-19 Vaccine AstraZeneca in pregnant or breastfeeding women. The majority of these cases occurred within the first four weeks following vaccination. Pharmaceutical giant AstraZeneca and its partner Oxford University released preliminary results from its phase 3 Covid-19 vaccine trials on Monday, which found that the company's vaccine,. 3. The second injection can be given between 4 and 12 weeks after the first injection. However, maintaining a homologous schedule is still acceptable. 0000024916 00000 n AstraZeneca published an interim analysis of clinical trials showing that its Covid vaccine had an average efficacy of 70% in protecting against the virus . COVID-19 Vaccine (ChAdOx1-S* recombinant) 5 10^10 viral particles (vp). If you have a previous diagnosis of capillary leak syndrome (a condition causing fluid leakage from small blood vessels). %PDF-1.3 % When autocomplete results are available use up and down arrows to review and enter to select. 0000001596 00000 n Store in a refrigerator (2C to 8C). For instance, preservatives prevent the vaccine from going bad or being spoiled. endstream 0000000016 00000 n The AstraZeneca vaccine is made up of a number of ingredients, including an active ingredient called an 'antigen' and several other non-active ingredients called 'excipients.' Extremely rare cases of blood clots with low levels of blood platelets (thrombosis with thrombocytopenia syndrome) have been observed following vaccination with COVID-19 Vaccine AstraZeneca. endobj Further to this, SAGE recommends that severe and moderately immunocompromised persons should be offered an additional dose of vaccine. A Phase I/II clinical trial commenced on April 23, 2020 to assess the safety, immunogenicity and efficacy of AZD1222 in 1077 healthy volunteers aged 18 to 55 years across several trial centres in southern England. 0000104331 00000 n 0000014217 00000 n 6`CA$'i$W30120ma`$p@ J Success! Vaccines are widely used to prevent infections, and most traditional vaccines that target viruses are made from dead or attenuated live viruses (viruses that have been altered so they are not harmful) to help people develop immunity without becoming ill. The recommended dosage is two doses given intramuscularly (0.5ml each) with an interval of 8 to 12 weeks. Results from a large clinical trial in the United States and South America indicate that AstraZeneca's COVID-19 vaccine, AZD1222, is well-tolerated and protects against symptomatic COVID-19 disease, including severe disease or hospitalization. 0000103790 00000 n Each vial contains 8 doses of 0.5 ml. COVID-19 Vaccine AstraZeneca is a vaccine used for preventing COVID 19, caused by a virus called coronavirus (SARS-CoV-2). A: None of the authorized COVID-19 vaccines in use in Canada contain the live virus that causes COVID-19. A very rare adverse event called Thrombosis with Thrombocytopenia Syndrome (TTS), involving unusual and severe blood clotting events associated with low platelet counts, has been reported after vaccination with this vaccine. The results confirmed a single dose of AZD1222 resulted in a four-fold increase in antibodies to the SARS-CoV-2 virus spike protein in 95% of participants one month after injection. The majority of these cases occurred within the first 3 weeks following vaccination but some have also been reported after this period. [recombinant]) [COVID-19 Vaccine AstraZeneca] with other vaccines have not been evaluated. Use all vaccine in the vial within 6 hours after first puncture. Dont worry we wont send you spam or share your email address with anyone. 0 2021 Jan 9;397(10269):72-74. doi: 10.1016/S0140-6736(20)32623-4. AstraZeneca . For countries that have not yet achieved high vaccine coverage rates in the high-priority groups and that are experiencing high incidence of COVID-19 cases combined with vaccine supply constraints, longer intervals i.e. This remarkable achievement is much-needed good news as COVID-19 cases are currently at their highest daily levels globally.2 . The vaccine does not contain any preservative and should be administered by a healthcare professional. 0000093244 00000 n 0 This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. The Anglo-Swedish firm has . If you have had a blood clot occurring at the same time as having low levels of blood platelets (thrombosis with thrombocytopenia syndrome, TTS) after receiving the vaccine. Six of the 28 died from their clotting complications. Talk to the healthcare provider if you have questions. 0000015637 00000 n If you are immunocompromised and receive a third dose of COVID-19 Vaccine AstraZeneca, it may still not provide full immunity to COVID-19 and you should continue to maintain physical precautions to help prevent COVID-19. WHO does not recommend discontinuing breastfeeding because of vaccination. None of the ingredients in this vaccine can cause COVID-19. Providing this In clinical trials there were very rare reports of events associated with inflammation of the nervous system, which may cause numbness, pins and needles, and/or loss of feeling. . How COVID-19 Vaccine AstraZeneca is given 4. 0000003223 00000 n x]n@FwezA"+q*z B-csD"%;>3a,7Mg>;M1crUukGavi%. Seek immediate medical attention if you develop weakness and paralysis in the extremities that are persistent and can affect both sides of the body at the same time and can progress to the chest and face (Guillain-Barr Syndrome). Do not freeze. 0000104953 00000 n % 0000003465 00000 n Pack sizes (not all pack sizes may be marketed): MedImmune UK Ltd 0000016862 00000 n Function. If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor, pharmacist or nurse for advice before you receive this vaccine. 2.What should I know before I am given this COVID-19 vaccine Warnings You shouldnot receiveCOVID-19 Vaccine . trailer <<082F7B1BF056430DB0F4C36E6FE6E521>]/Prev 207227>> startxref 0 %%EOF 96 0 obj <>stream If you forget to go back at the scheduled time, ask your doctor, pharmacist or nurse for advice. This will help to protect you against COVID-19 in the future. M Ms CZHto ) 4.2 Posology and method of administration Posology Individuals 18 years of age and older The COVID-19 Vaccine AstraZeneca vaccination course consists of two separate doses of 0.5 ml each. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Active ingredient: . You have accepted additional cookies. COVID-19 Vaccine AstraZeneca is given to adults aged 18 years and older. FDA Approved: No This includes any possible side effects not listed in this leaflet. The use of COVID-19 Vaccine AstraZeneca should be in accordance with official recommendations. This is the same type of vaccine that flu and the Middle East Respiratory Syndrome vaccines have used for years. endstream endobj startxref Updated on 13 June 2022 to ensure consistency of formatting. Contact your doctor or healthcare professional immediately or go to the nearest hospital emergency room right away if you have an allergic reaction. dwS(V"2G %[CA+|}e9;(al-U c9.3T@k w Blood clots in the brain, not associated with low level of blood platelets have been observed very rarely following vaccination with COVID-19 Vaccine AstraZeneca. Wed like to set additional cookies to understand how you use GOV.UK, remember your settings and improve government services. Solution for injection. Efficacy. To help pregnant women make this assessment, they should be provided with No substantive data are available related to impact of the vaccine on transmission or viral shedding. COVID-19 Vaccine AstraZeneca contains sodium and alcohol). 0000009594 00000 n The COVID-19 vaccines currently approved for use in the UK are: Moderna (Spikevax) Pfizer/BioNTech (Comirnaty) Novavax (Nuvaxovid) AstraZeneca (Oxford) (not available) Janssen (Johnson & Johnson) (not available) Valneva (Valneva) (not available) Which vaccine will I get? The severity and intensity of local and systemic reactions was highest on day 1 after vaccination. The AstraZeneca COVID-19 vaccine, now called Vaxzevria, is a viral vector vaccine, just like the Johnson & Johnson vaccine. Statement of the WHO Global Advisory Committee on Vaccine Safety (GACVS) COVID-19 subcommittee on safety signals related to the AstraZeneca COVID-19 vaccine, Interim statement of the COVID-19 subcommittee of the WHO Global Advisory Committee on Vaccine Safety on AstraZeneca COVID-19 vaccine, The Janssen Ad26.COV2.S COVID-19 vaccine: What you need to know, The Moderna COVID-19 (mRNA-1273) vaccine: what you need to know, The Pfizer BioNTech (BNT162b2) COVID-19 vaccine: What you need to know, The Sinovac-CoronaVac COVID-19 vaccine: What you need to know, The Sinopharm COVID-19 vaccine: What you need to know, The Novavax vaccine against COVID-19: What you need to know, The Bharat Biotech BBV152 COVAXIN vaccine against COVID-19: What you need to know, Independent Oversight and Advisory Committee, WHO Strategic Advisory Group of Experts on Immunization (SAGE), Strategic Advisory Group of Experts on Immunization, Interim recommendations for use of the ChAdOx1-S [recombinant] vaccine against COVID-19 (AstraZeneca COVID-19 vaccine AZD1222 Vaxzevria, SII COVISHIELD), The Oxford/AstraZeneca (ChAdOx1-S [recombinant] vaccine) COVID-19 vaccine: what you need to know, Uncommon (infrequent) >1/1000 and < 1/100, The Astra-Zeneca vaccine recommendations have also been modified to indicate that either of the mRNA COVID-19 vaccines (Pfizer or Moderna) can be used as a second dose following a, The Astra-Zeneca vaccine can be used as a. That way, when a person is exposed to COVID-19, its immune system will recognize the part of the virus that has those spike proteins and will know how to how to fight it. up to 16 weeks can be considered. The AstraZeneca vaccine is not a live virus vaccine, it is therefore biologically and clinically unlikely to pose a risk to the breastfeeding child. Some affected patients had a previous diagnosis of CLS. 0000011249 00000 n This type of vaccine technology has been tested for many other diseases such as influenza (flu) and middle east respiratory . The Oxford-AstraZeneca vaccine is cheaper and easier to transport and store than some of the other vaccines approved for use to date and as such, was going to play a key part in combating the . Like all medicines, this vaccine can cause side effects, although not everybody gets them. 0000056130 00000 n stream Published March 31, 2021 Updated Aug. 1, 2021. You may need to read it again. 3.What if I am taking, have recently taken or might take other medicinesor Stabilizers, like L-histidine or sucrose, make sure the vaccine is able to stay effective during the times it is transported and stored.. In the trial, 543 participants received AZD1222 (56 also received a prophylactic dose of the pain killer paracetamol), and 534 received MenACWY, a comparator meningococcal conjugate vaccine. hb```b``9 |Abl,=@00M(P~. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Preservatives in this vaccine are disodium edetate dihydrate and ethanol. serious nerve inflammation, which may cause paralysis and difficulty breathing (Guillain-Barr endstream endobj 76 0 obj <> stream Vaxzevria is a vaccine for preventing coronavirus disease 2019 (COVID-19) in people aged 18 years and older. Component. These include: y z(2$bW*; ! 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